We acknowledge past and ongoing funding supports from
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2022.9 We are awarded a NIH Director’s New Innovator award of >$2.2M from the The NIH Common Fund and National Institute Of General Medical Sciences (NIGMS) to develop an on-chip single-molecule protein sequencing (SMPS) technology. The research project will leverage our strengths in exploring multiple disciplines in engineering (nanofabrication, nanofluidics, photonic metasurface), biochemistry, and machine learning, to create a new platform that is rapid, inexpensive and versatile. SMPS of this kind holds the potential to revolutionize diagnostic medicine through the identification of protein biomarkers for cancer and other deadly diseases, provide earlier and more accurate diagnoses and deepen our understanding of how healthy cells function.
Please read the news release here:
2022.5 We are awarded a NIH R21 grant from the National Institute of Allergy and Infectious Diseases (NIAID) to develop a technology to rapidly detect and quantify the neutralizing antibodies against different SARS-CoV-2 variants. Such a technology would be very useful to identify the protection from new surging Omicron variants, which have shown great immunity-escape potential. This new research project is in collaboration with Dr. Neal Woodbury and Dr. Brenda Hogue at ASU.
Please read the abstract here:
2022.5 We are awarded $750k to combat African swine fever (ASF) disease in collaboration with Centro de Investigación en Sanidad Animal, CISA/INIA-CSIC, in Spain. This new research project is sponsored by the Agriculture and Food Research Initiative (AFRI) Competitive Grants Program from USDA/NIFA. Here is a new releases that provides a good review of the project.
Simple, inexpensive diagnostic technology to combat global threat of African Swine Fever | Biodesign Institute | ASU
2020.8 Dr. Wang is supported by NSF for DNA based storage and readout technologies .(https://www.nsf.gov/awardsearch/showAward?AWD_ID=2027215)
This SemiSynBio II award supports our collaboration with Prof. Hao Yan and Prof. Rizal Hariadi to explore the programmability of DNA nanostructures for the encryption keys, making it practically impossible to intercept and break the encryption. The research team will embed encrypted information in three-dimensional DNA origami nanostructures in the form of nanoscopic patterns. The high spatial resolution of DNA-PAINT (DNA-based point accumulation for imaging in nanoscopic topography) (<20 nm) and sapphire-supported nanopore sensors (<10 nm) will support high-density information decryption of intricate single-molecule patterns on the DNA origami, while enabling a fast readout speed of up to 1 MHz. The fast readout methods will employ deep-learning classification techniques for automated decryption and improved accuracy.
2020.4 Dr. Wang is supported by NSF to develop an new sapphire based nanopore device for low-noise DNA sensing.(https://www.nsf.gov/awardsearch/showAward?AWD_ID=2020464)
This NSF-BSF award supports our collaboration with Prof. Amit Meller at Technion to carry out fundamental research to create a significantly improved nanopore sensor platform that integrates low-optical background titanium oxide membranes on low-capacitance and hence low-electrical-noise sapphire. The research team will fabricate small and thin TiO2 membranes on sapphire, establish high-throughput manufacturing methods for both membrane formation and nanopore drilling, perform single-molecule DNA translocation, study the DNA-nanopore interaction, and analyze the data for methylation detection.
2019.12 Dr. Wang and collaborator Dr. Yu Yao are supported by NSF to develop an additive manufacturing method to print silver structures with micrometer resolution and at ambient conditions for functional electronic and photonic applications.(https://www.nsf.gov/awardsearch/showAward?AWD_ID=1947753)
2019.11 Dr. Wang and collaborator Dr. Yu Yao are supported by DOE to develop a polarimetric imaging system to attach to drones and deployed to evaluate the performance of concentrating solar-thermal power (CSP) collector systems.(https://www.energy.gov/eere/solar/seto-fy2019-concentrating-solar-thermal-power
2019.02 Dr. Wang is awarded the NSF CAREER award to investigate a new strategy towards early-stage cancer diagnostics using liquid biopsy on an integrated optofluidic chip. (https://nsf.gov/awardsearch/showAward?AWD_ID=1847324)
2018.08 Dr. Wang and collaborator Dr. Yu Yao are supported by NSF to develop an ultracompact on-chip integrated metasurface polarimetric imager.(https://www.nsf.gov/awardsearch/showAward?AWD_ID=1809997)
2018.07 Dr. Wang and collaborators Dr. Sefaattin Tongay and Dr. Yu Yao are supported by NSF to explore new strategies to integrate quantum emitter arrays in 2D artificial superlattices with nanophotonic structures towards room temperature quantum logic operations. (https://www.nsf.gov/awardsearch/showAward?AWD_ID=1838443)
2017.07 Dr. Wang is supported by NSF to collaborate with researchers at Iowa State University to design a silicon based nano-opto-fluidic chip for rapid exosome profiling. (https://www.nsf.gov/awardsearch/showAward?AWD_ID=1711412)
